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SEARCHBreast Model IDSB_0009 (version 2)
Model Submission Date2014-07-03
Model TypeGEMM
Model Name BlgCre Ptenf/f p53f/f
JAX Number -
DescriptionCre active in luminal ER negative progenitor cells; floxed conditional Pten and p53 alleles
GEMM AlleleBlgCre Pten p53
Common Names-
Strain Predominantly C57/Bl6
Sex Female
Develops Mammary TumoursYes
Preneoplastic Lesions Yes
Develops Metastasis No
ER Mixed positive and negative
PR Mixed positive and negative
HER2 Not determined by this investigator
Origin Luminal
CK5 Not determined by this investigator
CK8 Not determined by this investigator
p63 Mixed positive and negative
SMA Not determined by this investigator
CKOtherYes:Mixed positivity for CK14 and CK 18
Metastasis Site-
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance -
Metastasis Liver Penetrance-
Material AvailableMice / Mammary tumour (Mice subject to third party MTAs)
Material Storage
Mammary tumourFrozen FFPE
AnalysesGeneral histology; Transcriptome analysis;
ReferenceIdentification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. Melchor L1, Molyneux G, Mackay A, Magnay FA, Atienza M, Kendrick H, Nava-Rodrigues D, L�pez-Garc�a M�, Milanezi F, Greenow K, Robertson D, Palacios J, Reis-Filho JS, Smalley MJ. J Pathol. 2014 Jun;233(2):124-37. doi: 10.1002/path.4345.
PubMed ID24615332
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes Tumours generate four histological phenotypes - Invasive Ductal Carcinoma of No Special Type (IDC-NST); adenosquamous tumours; adenomyoepitheliomas; metaplastic spindle cell carcinomas

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