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SEARCHBreast Model IDSB_0026 (version 1)
Model Submission Date2015-01-13
Model TypeXenograft
Model Name-
Strain CD1-Nude
Sex Female
Site Subcutaneous - flank
Cell LineMDA-MB-436
Material Available- (-)
Material Storage
TumourFFPE
Long bonesFFPE
Therapy Available Yes
Therapy Control (0.1mls PBS), 100ug/kg zoledronic acid, 2mg/kg doxorubicin or 100ug/kg zoledronic acid followed 24h later by 2mg/kg doxorubicin. All treatments were given once per week for 4 weeks
Analyses Tumour volume; General histology; Vascularisation; Immune infiltrate; Apoptosis; Proliferation; Gene expression; Other;
ReferenceSustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model. Ottewell PD, Lefley DV, Cross SS, Evans CA, Coleman RE, Holen I. Int J Cancer. 2010 Jan 15;126(2):522-32.
PubMed ID 19621384
Additional References -
Additional References PubMed IDs
Study Molecule -
Notes -

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