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SEARCHBreast Model IDSB_0027 (version 1)
Model Submission Date2015-01-13
Model TypeXenograft
Model Name-
Strain CD1-Nude
Sex Female
Site Intra-tibial
Cell LineMDA-MB-436
Material AvailableTumour (-)
Material Storage
TumourFFPE
Long bonesFFPE
Therapy Available Yes
Therapy Control (0.1mls PBS), 100ug/kg zoledronic acid, 2mg/kg doxorubicin or 100ug/kg zoledronic acid followed 24h later by 2mg/kg doxorubicin. All treatments were given once per week for 6 weeks
Analyses Tumour volume; General histology; Vascularisation; Apoptosis; Proliferation; Gene expression;
Reference12. Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone. Ottewell PD, Woodward JK, Lefley DV, Evans CA, Coleman RE, Holen I. Mol Cancer Ther. 2009 Oct;8(10):2821-32.
PubMed ID 19789217
Additional References -
Additional References PubMed IDs-
Study Molecule -
Notes -

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