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SEARCHBreast Model IDSB_0032 (version 1)
Model Submission Date2015-01-13
Model TypeXenograft
Model Name-
Strain BALB/c-Nude
Sex Female
Site Intracardiac
Cell LineMDA-MB-231
Material AvailableLong bones (A limited supply of tumour RNA/DNA and frozen samples are available from this study)
Material Storage
TumourFFPE
Long bonesFFPE
Therapy Available Yes
Therapy Mice were ovariectomised or sham operated 7 before/after intra cardiac injection of MDA-MB-231 cells. Mice were then administered 100ug/kg zoledronic acid or PBS (control) once per week for 4 weeks
Analyses Tumour volume; Gene expression;
ReferenceZoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo. Ottewell PD, Wang N, Brown HK, Reeves KJ, Fowles CA, Croucher PI, Eaton CL, Holen I. Clin Cancer Res. 2014 Jun 1;20(11):2922-32.
PubMed ID 24687923
Additional References -
Additional References PubMed IDs-
Study Molecule -
Notes -

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