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SEARCHBreast Model IDSB_0033 (version 3)
Model Submission Date2015-01-20
Model TypeGEMM
Model Name MMTV-PyMT (FVB)
JAX Number 02374
DescriptionThese transgenic mice have the polyoma virus middle T antigen (PyVT) under control of the mouse mammary tumour virus (MMTV) promoter/enhancer. Females develop mammary tumours which often (strain dependent) metastasize to the lungs. Males develop mammary tumours with longer latency. Pulmonary metastases are observed in 80-94% of tumour-bearing female mice.
GEMM AlleleMMTV-PyMT
Common NamesMMTV-PyMT; MMTV-PyVmT; MT634; MTAG; PyMT; PyV-mT; PyVT; Tg(MMTVPyVT)634Mul;
Strain FVB
Sex Female
Develops Mammary TumoursYes
Preneoplastic Lesions Yes
Develops Metastasis Yes
ER -
PR -
HER2 Negative
Origin -
CK5 -
CK8 -
p63 -
SMA -
CKOther-
Metastasis SiteLung;
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance 0-100%
Metastasis Liver Penetrance-
Material AvailableMice / Mammary tumour / Mammary gland (preneoplastic) / Mammary epithelial cells / Lung metastasis (-)
Material Storage
MiceLive Sperm
Mammary tumourFrozen FFPE Other
Mammary gland (preneoplastic)Frozen FFPE
Mammary epithelial cellsFrozen Other
Lung metastasisFFPE
AnalysesTumour volume; General histology; Immune infiltrate;
ReferenceGuy CT; Cardiff RD; Muller WJ. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-61.
PubMed ID 1312220
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes -

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