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SEARCHBreast Model IDSB_0035 (version 1)
Model Submission Date2015-01-20
Model TypeGEMM
Model Name K14-Cre
JAX Number 004782
DescriptionThese transgenic mice express Cre recombinase under the control of the human keratin 14 promoter. Used for activation of conditional GEM alleles in K14+ epithelial lineage.
GEMM AlleleK14-Cre
Common NamesK14-Cre; K14 cre; K14-cre; K14cre; Krt14^Cre
Strain FVB
Sex Female
Develops Mammary TumoursNot applicable
Preneoplastic Lesions -
Develops Metastasis No
ER No information provided
PR No information provided
HER2 No information provided
Origin -
CK5 No information provided
CK8 No information provided
p63 No information provided
SMA No information provided
Metastasis Site-
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance -
Metastasis Liver Penetrance-
Material AvailableMice / Whole mammary gland (normal) (-)
Material Storage
Whole mammary gland (normal)Frozen FFPE
ReferenceDassule HR; Lewis P; Bei M; Maas R; McMahon AP. 2000. Sonic hedgehog regulates growth and morphogenesis of the tooth Development 127(22):4775-85.
PubMed ID11044393
Additional References Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A: Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 2001, 29:418–25.
Additional References PubMed IDs11694875
Therapy -
Genetic Studies-
Notes -

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