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SEARCHBreast Model IDSB_0039 (version 2)
Model Submission Date2015-01-26
Model TypeGEMM
Model Name MMTV-Runx2
JAX Number n/a
DescriptionTransgenic mouse with MMTV promoter driven expression of ectopic Runx2 (2 independent lines)
GEMM AlleleMMTV-Runx2
Common Names-
Strain FVB
Sex M/F mixed collection
Develops Mammary TumoursNo
Preneoplastic Lesions -
Develops Metastasis No
ER -
PR -
HER2 -
Origin -
CK5 -
CK8 -
p63 -
SMA -
CKOther-
Metastasis Site-
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance -
Metastasis Liver Penetrance-
Material AvailableMice / Mammary gland (preneoplastic) / Whole mammary gland (normal) (-)
Material Storage
MiceEmbryos Sperm
Mammary gland (preneoplastic)Frozen FFPE
Whole mammary gland (normal)Frozen FFPE Other
AnalysesGeneral histology;
ReferenceRUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. McDonald L, Ferrari N, Terry A, Bell M, Mohammed ZM, Orange C, Jenkins A, Muller WJ, Gusterson BA, Neil JC, Edwards J, Morris JS, Cameron ER, Blyth K. Dis Model Mech. 2014 May;7(5):525-34.
PubMed ID24626992
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes -

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