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SEARCHBreast Model IDSB_0047 (version 1)
Model Submission Date2015-07-10
Model TypeXenograft
Model Name-
Strain Rag2-/- Il2rg-/-
Sex Female
Site Mammary fat pad
Cell LineMDA-MB-231
Material AvailableMammary fat pad (tumour) / Lung / Spleen / Liver (-)
Material Storage
Mammary fat pad (tumour)Frozen
LungFrozen
SpleenFrozen
LiverFrozen
Therapy Available Yes
Therapy Phenytoin 60 mg/kg or vehicle by daily ip injection for 3 weeks starting 1 week after orthotopic implantation.
Analyses Tumour volume; General histology; Vascularisation; Apoptosis; Proliferation;
ReferenceNelson M, Yang M, Dowle AA, Thomas JR & Brackenbury WJ. (2015). The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer 14, 13.
PubMed ID 25623198
Additional References Nelson M, Millican-Slater R, Forrest LC & Brackenbury WJ. (2014). The sodium channel beta1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis. Int J Cancer 135, 2338-2351.
Additional References PubMed IDs 24729314
Study Molecule Overexpression of SCN1B in MDA-MB-231 cells in some samples.
Notes -

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