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SEARCHBreast Model IDSB_0049 (version 1)
Model Submission Date2015-11-25
Model TypeGEMM
Model Name MMTV-Erbb2
JAX Number 005038
DescriptionThese transgenic mice express the ACTIVATED rat c-neu oncogene (Erbb2/Her2) under the control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter. Both females and males develop mammary tumours.
GEMM AlleleMMTV-Erbb2
Common NamesMMTV-Erbb2; HER-2/neu; MMTV-erbB2; MMTV-neu; TG.NK; Tg(MMTV-Erbb2)1Led
Strain FVB
Sex Female
Develops Mammary TumoursYes
Preneoplastic Lesions Yes
Develops Metastasis Yes
ER No information provided
PR No information provided
HER2 No information provided
Origin -
CK5 No information provided
CK8 No information provided
p63 No information provided
SMA No information provided
Metastasis SiteLung;
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance 0-40%
Metastasis Liver Penetrance-
Material AvailableMice / Mammary tumour / Mammary epithelial cells / Lung metastasis (-)
Material Storage
MiceLive Embryos
Mammary tumourFrozen FFPE
Mammary epithelial cellsFrozen
Lung metastasisFFPE
ReferenceMuller WJ; Sinn E; Pattengale PK; Wallace R; Leder P. 1988. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54(1):105-15.
PubMed ID2898299
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes -

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