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SEARCHBreast Model IDSB_0067 (version 1)
Model Submission Date2016-04-28
Model TypeGEMM
Model Name MMTV-PyMT (BL6)
JAX Number 022974
DescriptionThese transgenic mice have the polyoma virus middle T antigen (PyVT) under control of the mouse mammary tumour virus (MMTV) promoter/enhancer. Females develop mammary tumours which often (strain dependent) metastasize to the lungs. Males develop mammary tumours with longer latency. Tumour-bearing females have reduced lung metastasis compared to FVB.
GEMM AlleleMMTV-PyMT
Common NamesMMTV-PyMT; MMTV-PyVmT; MT634; MTAG; PyMT; PyV-mT; PyVT; Tg(MMTVPyVT)634Mul;
Strain C57Bl/6
Sex Female
Develops Mammary TumoursYes
Preneoplastic Lesions Yes
Develops Metastasis Yes
ER No information provided
PR No information provided
HER2 No information provided
Origin -
CK5 No information provided
CK8 No information provided
p63 No information provided
SMA No information provided
CKOther-
Metastasis SiteLung;
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance 0-20%
Metastasis Liver Penetrance-
Material Available- (-)
Material Storage
MiceLive
Mammary tumourFrozen FFPE
Mammary epithelial cellsFrozen
Lung metastasisFFPE
AnalysesTumour volume; General histology;
Reference-
PubMed ID-
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes -

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