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SEARCHBreast Model IDSB_0068 (version 1)
Model Submission Date2016-05-29
Model TypeGEMM
Model Name MMTV-Cre (BL6)
JAX Number 003553
DescriptionThis transgenic strain expresses Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter. The MMTV LTR promoter directs a widespread pattern of expression. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B cells and T cells. Little background recombination was observed in the lung, kidney, liver and brain tissues (less than 10%). The donating investigator indicates that this strain may be suitable for use in applications where it is desirable to delete genes in the virgin and lactating mammary gland, skin, erythroid cells, and other secretory tissues and skin.
GEMM AlleleTg(MMTV-cre)4Mam
Common NamesMMTV-Cre
Strain C57Bl/6
Sex M/F mixed collection
Develops Mammary TumoursNo
Preneoplastic Lesions No
Develops Metastasis No
ER No information provided
PR No information provided
HER2 No information provided
Origin -
CK5 No information provided
CK8 No information provided
p63 No information provided
SMA No information provided
Metastasis Site-
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance -
Metastasis Liver Penetrance-
Material Available- (-)
Material Storage
ReferenceAmplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Andrechek ER, Hardy WR, Siegel PM, Rudnicki MA, Cardiff RD, Muller WJ. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3444-9
PubMed ID10716706
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes We have crossed this line with a reporter and have detailed information on Cre expression.

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