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SEARCHBreast Model IDSB_0070 (version 2)
Model Submission Date2016-05-29
Model TypeGEMM
Model Name Blg-Cre_B-catenin
JAX Number -
DescriptionTo understand the role of stabilized beta-catenin in tumorigenesis in mice, a PGK-neomycin resistance cassette introduced two loxP sites flanking exon 3 and the inserted cassette. When the germline heterozygotes were crossed with mice expressing Cre recombinase under the control of a sheep beta-lactoglobulin promoter (LGB) in the mammary, the serines and threonine encoded by exon 3 and to be phosphorylated by glycogen synthase kinase 3beta (GSK3beta).
GEMM AlleleTg(LGB-cre)74Acl, Ctnnb1tm1Mmt
Common NamesBlg-Cre_beta-cat c.a.; BLG-Cre_Bcat-ex3
Strain FVB
Sex M/F mixed collection
Develops Mammary TumoursYes
Preneoplastic Lesions Yes
Develops Metastasis No
ER -
PR -
HER2 -
Origin Basal
CK5 Positive
CK8 -
p63 -
SMA Positive
CKOther-
Metastasis Site-
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance -
Metastasis Liver Penetrance-
Material Available- (Lungs FFPE)
Material Storage
MiceLive
Mammary tumourFrozen FFPE
Mammary gland (preneoplastic)Frozen FFPE
Whole mammary gland (normal)Frozen FFPE
LiverFFPE
AnalysesGeneral histology; Proliferation;
Reference-
PubMed ID-
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes -

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