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SEARCHBreast Model IDSB_0071 (version 1)
Model Submission Date2016-05-29
Model TypeGEMM
Model Name Blg-Cre_ZEG
JAX Number -
DescriptionBeta-lactoglobin driven Cre recombinase transgene used for mammary specific activation of conditional GEM alleles; hormonally regulated. The ZEG transgene contains a CMV enhancer/chicken beta actin promoter, a segment consisting of floxed lacZ and neomycin resistance genes/SV40 polyadenylation signal, and an enhanced GFP reporter gene followed by a rabbit beta-globin polyadenylation sequence. Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages.
GEMM AlleleTg(LGB-cre)74Acl , Tg(CAG-Bgeo/GFP)21Lbe
Common NamesBlg-Cre_Z/EG
Strain Mixed genetic strain
Sex M/F mixed collection
Develops Mammary TumoursNo
Preneoplastic Lesions No
Develops Metastasis No
ER No information provided
PR No information provided
HER2 No information provided
Origin -
CK5 No information provided
CK8 No information provided
p63 No information provided
SMA No information provided
CKOther-
Metastasis Site-
Metastasis Bone Penetrance -
Metastasis Brain Penetrance-
Metastasis Lung Penetrance -
Metastasis Liver Penetrance-
Material Available- (-)
Material Storage
MiceLive
Whole mammary gland (normal)Frozen FFPE
AnalysesGeneral histology; Proliferation;
Reference-
PubMed ID-
Additional References -
Additional References PubMed IDs-
Therapy -
Genetic Studies-
Notes -

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