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  72 models match this search:

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    SEARCHBreast IDModel TypeStrainSiteCell LineModel NameGEMM AlleleDescription
    1
    SB_0001XenograftBALB/c-NudeIntracardiac-MDA-MB-231 Bone Metastasis Model--
    2
    SB_0008GEMM----FKBPL+/neo and FKBPL+/-one allele of anti-angiogenic protein, FKBPL, knocked down in exon 2 by targeted neomycin cassette (FKBPL+/neo). Also have FKBPL +/-
    3
    SB_0009GEMM---BlgCre Ptenf/f p53f/fBlgCre Pten p53Cre active in luminal ER negative progenitor cells; floxed conditional Pten and p53 alleles
    4
    SB_0019Other-----Hollow Fibre Assay
    5
    SB_0025XenograftMF1 nudeSubcutaneous - flankMDA-MB-436---
    6
    SB_0026XenograftCD1-NudeSubcutaneous - flankMDA-MB-436---
    7
    SB_0027XenograftCD1-NudeIntra-tibialMDA-MB-436---
    8
    SB_0028XenograftBALB/c-NudeIntracardiacMDA-MB-231---
    9
    SB_0029GEMM---MMTV-PyMT (FVB)MMTV-PyMTThese transgenic mice have the polyoma virus middle T antigen (PyVT) under control of the mouse mammary tumour virus (MMTV) promoter/enhancer. Females develop mammary tumours which often (strain dependent) metastasize to the lungs. Males develop mammary tumours with longer latency. Pulmonary metastases are observed in 80-94% of tumour-bearing female mice.
    10
    SB_0030XenograftBALB/c-NudeMammary fat padMCF7---
    11
    SB_0031XenograftBALB/c-NudeMammary fat padT47D---
    12
    SB_0032XenograftBALB/c-NudeIntracardiacMDA-MB-231---
    13
    SB_0033GEMM---MMTV-PyMT (FVB)MMTV-PyMTThese transgenic mice have the polyoma virus middle T antigen (PyVT) under control of the mouse mammary tumour virus (MMTV) promoter/enhancer. Females develop mammary tumours which often (strain dependent) metastasize to the lungs. Males develop mammary tumours with longer latency. Pulmonary metastases are observed in 80-94% of tumour-bearing female mice.
    14
    SB_0034GEMM---Blg-CreBlg-Crebeta-lactoglobin driven Cre recombinase transgene used for mammary specific activation of conditional GEM alleles; hormonally regulated.
    15
    SB_0035GEMM---K14-CreK14-CreThese transgenic mice express Cre recombinase under the control of the human keratin 14 promoter. Used for activation of conditional GEM alleles in K14+ epithelial lineage.
    16
    SB_0036XenograftBALB/c-NudeIntracardiac-MDA-MB-231 Bone Metastasis Model--
    17
    SB_0037XenograftBALB/c-NudeIntracardiacMDA-MB-231---
    18
    SB_0039GEMM---MMTV-Runx2MMTV-Runx2Transgenic mouse with MMTV promoter driven expression of ectopic Runx2 (2 independent lines)
    19
    SB_0040GEMM---MMTV-CreMMTV-CreThis transgenic strain expresses P1 Cre recombinase under the control of the MMTV LTR promoter. Used for mammary specific activation of conditional GEM alleles; hormonally regulated. Note there are various lines of MMTV-Cre with different phenotypes.
    20
    SB_0041XenograftCD1-NudeMammary fat pad-MDA-MB-231 orthotopic--
    21
    SB_0044GEMM---Blg-CreBlg-Crebeta-lactoglobin driven Cre recombinase transgene used for mammary specific activation of conditional GEM alleles; hormonally regulated.
    22
    SB_0045GEMM---Zfp157LacZ--
    23
    SB_0046Other-----Conditionally immortal mouse mammary epithelial cell line derived from mid-pregnant mouse
    24
    SB_0047XenograftRag2-/- Il2rg-/- Mammary fat padMDA-MB-231---
    25
    SB_0048GEMM---Blg-Cre:Brca1^f/f:p53^+/-Blg-Cre, Brca1-flox, Trp53-KOBLG-Cre: Brca1^f/f: Trp53^+/- mice that carry the beta-lactoglobulin Cre (BLG-Cre) transgene are homozygous for floxed exons 22-24 of the breast cancer 1 (Brca1) allele, and are heterozygous for p53 tumour-suppressor gene (Trp53) deficiency. Expression of the BLG-Cre transgene during lactation in females leads to loss of Brca1 function in the mammary gland. This results in formation of mammary tumours exhibiting high grade central necrosis and metaplastic elements in the form of spindle cell and squamous cell differentiation; as seen in human basal-like breast cancers and BRCA1 mutation carriers. Heterozygosity for the mutant p53 allele accelerates the formation of mammary tumours.
    26
    SB_0049GEMM---MMTV-Erbb2MMTV-Erbb2These transgenic mice express the ACTIVATED rat c-neu oncogene (Erbb2/Her2) under the control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter. Both females and males develop mammary tumours.
    27
    SB_0050PDXNSGSubcutaneous - flankPrimary patient materialPDX2-Late BC from a IDC (PE), Grade: 2, Receptor status:ER+,PGR+,HER2 -, subtype based on IHC: LUMINAL A
    28
    SB_0051PDXNSGSubcutaneous - flankPrimary patient materialPDX3-Late BC from a IDC (Asc), Grade: 2, Receptor status:ER+,PGR+,HER2 -, subtype based on IHC: LUMINAL A
    29
    SB_0052PDXNSGSubcutaneous - flankPrimary patient materialPDX4-Late BC from a IDC (Asc), Grade: 2, Receptor status:ER+,PGR+,HER2 -, subtype based on IHC: LUMINAL A
    30
    SB_0053PDXNSGSubcutaneous - flankPrimary patient materialPDX5-Late BC from a IDC (PE), Grade: 3, Receptor status:ER+,PGR+,HER2 +, subtype based on IHC: LUMINAL B
    31
    SB_0054PDXNSGSubcutaneous - flankPrimary patient materialPDX6-Early BC from a IDC, Grade: n/a, Receptor status:ER+,PGR+,HER2 -, subtype based on IHC: LUMINAL A
    32
    SB_0055PDXNSGSubcutaneous - flankPrimary patient materialPDX7-Early BC from a IDC, Grade: 3, Receptor status:ER+,PGR+,HER2 +, subtype based on IHC: LUMINAL B
    33
    SB_0056PDXNSGSubcutaneous - flankPrimary patient materialPDX8-Early BC from a IDC, Grade: 2, Receptor status:ER+,PGR+,HER2 -, subtype based on IHC: LUMINAL A
    34
    SB_0057PDXNSGSubcutaneous - flankPrimary patient materialPDX9-Early BC from a IDC/DCIS, Grade: 3, Receptor status:ER+,PGR-,HER2 +, subtype based on IHC: LUMINAL B
    35
    SB_0058PDXNSGSubcutaneous - flankPrimary patient materialPDX11-Early BC from a IDC, Grade: 2, Receptor status:ER-,PGR-,HER2 -, subtype based on IHC: TRIPLE NEG
    36
    SB_0059PDXNSGSubcutaneous - flankPrimary patient materialPDX1-Late BC from a ILC (Asc), Grade: n/a, Receptor status:ER+,PGR-,HER2 -, subtype based on IHC: LUMINAL A
    37
    SB_0060PDXNSGSubcutaneous - flankPrimary patient materialPDX10-Early BC from a IDC/DCIS, Grade: 3, Receptor status:ER+,PGR-,HER2 +, subtype based on IHC: LUMINAL B
    38
    SB_0061PDXNSGSubcutaneous - flankPrimary patient materialPDX12-Early BC from a IDC, Grade: 3, Receptor status:ER-,PGR-,HER2 -, subtype based on IHC: TRIPLE NEG
    39
    SB_0062PDXNSGSubcutaneous - flankPrimary patient materialPDX13-Early BC from a IDC/DCIS, Grade: 3, Receptor status:ER-,PGR-,HER2 -, subtype based on IHC: TRIPLE NEG
    40
    SB_0063PDXNSGSubcutaneous - flankPrimary patient materialPDX14-Early BC from a IDC, Grade: 3, Receptor status:ER-,PGR-,HER2 +, subtype based on IHC: HER 2 TYPE
    41
    SB_0064PDXNSGSubcutaneous - flankPrimary patient materialPDX15-Early BC from a IDC, Grade: 2, Receptor status:ER-,PGR-,HER2 -, subtype based on IHC: TRIPLE NEG
    42
    SB_0065PDXNSGSubcutaneous - flankPrimary patient materialPDX16-Late BC from a PE, Grade: 3, Receptor status:ER-,PGR-,HER2 -, subtype based on IHC: TRIPLE NEG
    43
    SB_0066PDXNSGSubcutaneous - flankPrimary patient materialPDX17-Early BC from a IDC/DCIS, Grade: 3, Receptor status:ER-,PGR-,HER2 -, subtype based on IHC: TRIPLE NEG
    44
    SB_0067GEMM---MMTV-PyMT (BL6)MMTV-PyMTThese transgenic mice have the polyoma virus middle T antigen (PyVT) under control of the mouse mammary tumour virus (MMTV) promoter/enhancer. Females develop mammary tumours which often (strain dependent) metastasize to the lungs. Males develop mammary tumours with longer latency. Tumour-bearing females have reduced lung metastasis compared to FVB.
    45
    SB_0068GEMM---MMTV-Cre (BL6)Tg(MMTV-cre)4MamThis transgenic strain expresses Cre recombinase under the control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter. The MMTV LTR promoter directs a widespread pattern of expression. High levels of recombination have been detected in the virgin and lactating mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B cells and T cells. Little background recombination was observed in the lung, kidney, liver and brain tissues (less than 10%). The donating investigator indicates that this strain may be suitable for use in applications where it is desirable to delete genes in the virgin and lactating mammary gland, skin, erythroid cells, and other secretory tissues and skin.
    46
    SB_0069GEMM---MMTV-Cre-RFPTg(MMTV-cre)4Mam, R26tdRFPThis transgenic strain expresses P1 Cre recombinase under the control of the MMTV LTR promoter. Used for mammary specific activation of conditional GEM alleles; hormonally regulated. This is a reporter allele for Cre activity that expresses a non-toxic tandem-dimer red fluorescent protein (2 modified DsRed subunits covalently linked) following Cre-mediated deletion of a floxed neo/stop cassette.
    47
    SB_0070GEMM---Blg-Cre_B-cateninTg(LGB-cre)74Acl, Ctnnb1tm1Mmt To understand the role of stabilized beta-catenin in tumorigenesis in mice, a PGK-neomycin resistance cassette introduced two loxP sites flanking exon 3 and the inserted cassette. When the germline heterozygotes were crossed with mice expressing Cre recombinase under the control of a sheep beta-lactoglobulin promoter (LGB) in the mammary, the serines and threonine encoded by exon 3 and to be phosphorylated by glycogen synthase kinase 3beta (GSK3beta).
    48
    SB_0071GEMM---Blg-Cre_ZEGTg(LGB-cre)74Acl , Tg(CAG-Bgeo/GFP)21LbeBeta-lactoglobin driven Cre recombinase transgene used for mammary specific activation of conditional GEM alleles; hormonally regulated. The ZEG transgene contains a CMV enhancer/chicken beta actin promoter, a segment consisting of floxed lacZ and neomycin resistance genes/SV40 polyadenylation signal, and an enhanced GFP reporter gene followed by a rabbit beta-globin polyadenylation sequence. Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages.
    49
    SB_0072GEMM---Blg-Cre_ZEGTg(LGB-cre)74Acl , Tg(CAG-Bgeo/GFP)21LbeBeta-lactoglobin driven Cre recombinase transgene used for mammary specific activation of conditional GEM alleles; hormonally regulated. The ZEG transgene contains a CMV enhancer/chicken beta actin promoter, a segment consisting of floxed lacZ and neomycin resistance genes/SV40 polyadenylation signal, and an enhanced GFP reporter gene followed by a rabbit beta-globin polyadenylation sequence. Expression of lacZ in transgenic mice is widespread, with notable exceptions being liver and lung tissue. This expression is observed throughout all embryonic and adult stages.
    50
    SB_0073XenograftCD1-NudeMammary fat padMDA-MB-468MDA-MB-468 orthotopic--
    51
    SB_0074XenograftCD1-NudeMammary fat padMDA-MB-231MDA-MB-231-luciferase-D3H2LN orthotopic--
    52
    SB_0075XenograftBALB/c-NudeSubcutaneous - flankMCFDCIS.comMCF10DCIS.com - subcutaneous--
    53
    SB_0076XenograftAthymic nudeSubcutaneous - flank-GEM derived-Beta catenin tumour fragment Tumour fragment - allograft--
    54
    SB_0094PDXNOD SCIDMammary fat padPrimary patient material---
    55
    SB_0095PDXBALB/c-NudeMammary fat padPrimary patient material---
    56
    SB_0096XenograftAppropriate for nude modelsSubcutaneous - flankMDA-MB-231Breast Cancer Cell Lines: TNBC--
    57
    SB_0097XenograftAppropriate for nude modelsSubcutaneous - flankSUM149 (LVP)Breast Cancer Cell Lines: TNBC--
    58
    SB_0098XenograftAppropriate for nude modelsSubcutaneous - flankSUM159 (LVP)Breast Cancer Cell Lines: TNBC--
    59
    SB_0099XenograftAppropriate for nude modelsSubcutaneous - flankHCC1187Breast Cancer Cell Lines: TNBC--
    60
    SB_0100XenograftAppropriate for nude modelsSubcutaneous - flankHCC1806Breast Cancer Cell Lines: TNBC--
    61
    SB_0101XenograftAppropriate for nude modelsSubcutaneous - flankMDA-MB-436Breast Cancer Cell Lines: TNBC--
    62
    SB_0102XenograftAppropriate for nude modelsSubcutaneous - flankMDA-MB-468Breast Cancer Cell Lines: TNBC--
    63
    SB_0103XenograftAppropriate for nude modelsSubcutaneous - flankHCC38Breast Cancer Cell Lines: TNBC--
    64
    SB_0104XenograftAppropriate for nude modelsSubcutaneous - flankCAL51Breast Cancer Cell Lines: TNBC--
    65
    SB_0105XenograftAppropriate for nude modelsSubcutaneous - flankHCC-1954Breast Cancer Cell Lines: Her2+--
    66
    SB_0106XenograftAppropriate for nude modelsSubcutaneous - flankSkbr3Breast Cancer Cell Lines: Her2+--
    67
    SB_0107XenograftAppropriate for nude modelsSubcutaneous - flankMCF7Breast Cancer Cell Lines: ER+--
    68
    SB_0108XenograftAppropriate for nude modelsSubcutaneous - flankBT474Breast Cancer Cell Lines: ER+--
    69
    SB_0109XenograftAppropriate for nude modelsSubcutaneous - flankT47DBreast Cancer Cell Lines: ER+--
    70
    SB_0110Other-----in vitro model of breast cancer
    71
    SB_0111SyngeneicBALB/cMammary fat pad----
    72
    SB_0112GEMM---Blg-CreBlg-Crebeta-lactoglobin driven Cre recombinase transgene used for mammary specific activation of conditional GEM alleles; hormonally regulated.

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